Giuseppe Gasparre Selected Research

Electron Transport Complex I (NADH-CoQ Reductase)

1/2022	Inducing respiratory complex I impairment elicits an increase in PGC1α in ovarian cancer.
10/2021	Respiratory Complex I dysfunction in cancer: from a maze of cellular adaptive responses to potential therapeutic strategies.
1/2019	Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.
5/2018	The Oncojanus Paradigm of Respiratory Complex I.
1/2017	Increase in proteins involved in mitochondrial fission, mitophagy, proteolysis and antioxidant response in type I endometrial cancer as an adaptive response to respiratory complex I deficiency.
6/2015	Targeting respiratory complex I to prevent the Warburg effect.
6/2014	Analysis of the mitochondrial proteome of cybrid cells harbouring a truncative mitochondrial DNA mutation in respiratory complex I.
3/2014	Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment.
3/2013	Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells.
1/2013	Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas.

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Giuseppe Gasparre Research Topics

Disease

50	Neoplasms (Cancer) 01/2022 - 05/2007
9	Hypoxia (Hypoxemia) 01/2021 - 03/2010
6	Ovarian Neoplasms (Ovarian Cancer) 01/2022 - 08/2011
6	Carcinoma (Carcinomatosis) 10/2021 - 06/2006
5	Carcinogenesis 01/2022 - 04/2008
5	Mitochondrial Diseases (Mitochondrial Disease) 10/2021 - 06/2006
5	Breast Neoplasms (Breast Cancer) 10/2017 - 05/2007
3	Osteosarcoma (Osteogenic Sarcoma) 12/2019 - 06/2006
3	renal Oncocytoma 01/2019 - 04/2008
3	Endometrial Neoplasms (Endometrial Cancer) 07/2018 - 06/2011
3	Hyperplasia 01/2017 - 06/2011
3	Glioblastoma (Glioblastoma Multiforme) 06/2015 - 09/2013
2	Vulvar Neoplasms (Vulvar Cancer) 04/2021 - 10/2015
2	Neoplasm Metastasis (Metastasis) 05/2018 - 10/2014
2	Tendinopathy (Tendonitis) 09/2017 - 07/2016
2	Neuroblastoma 08/2016 - 07/2006
2	Pain (Aches) 07/2016 - 10/2015
1	Adenocarcinoma of Lung 01/2022
1	Papillary Thyroid Cancer 01/2022
1	Hyperinsulinism (Hyperinsulinemia) 01/2022
1	Lung Neoplasms (Lung Cancer) 01/2022
1	Thyroid Neoplasms (Thyroid Cancer) 01/2022
1	Hyperammonemia 01/2022
1	Congenital Hyperinsulinism 01/2022
1	Adenoma (Adenomas) 10/2021
1	Hyperparathyroidism 2 10/2021
1	Multiple Primary Neoplasms 02/2021
1	Optic Atrophy 01/2021
1	Low Back Pain (Lumbago) 12/2019
1	Ovarian Epithelial Carcinoma 05/2019
1	Oxyphilic Adenoma (Oncocytoma) 01/2019
1	Pathologic Processes 01/2019
1	Spinocerebellar ataxia 28 01/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019
1	Partial Epilepsies (Epilepsy, Partial) 01/2019
1	Epilepsy (Aura) 01/2019

Drug/Important Bio-Agent (IBA)

38	Mitochondrial DNA (mtDNA)IBA 01/2022 - 06/2006
13	Electron Transport Complex I (NADH-CoQ Reductase)IBA 01/2022 - 04/2008
11	EnzymesIBA 01/2022 - 04/2008
5	DNA (Deoxyribonucleic Acid)IBA 03/2015 - 06/2006
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 03/2014
3	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 01/2019
2	AntioxidantsIBA 01/2022 - 01/2017
2	Cisplatin (Platino)FDA LinkGeneric 04/2021 - 01/2019
2	Oxygen (Dioxygen)IBA 01/2021 - 01/2017
2	Pharmaceutical PreparationsIBA 01/2020 - 01/2017
2	Sirolimus (Rapamycin)FDA Link 01/2019 - 11/2015
2	Proteins (Proteins, Gene)FDA Link 01/2017 - 06/2011
2	ParaffinIBA 03/2015 - 01/2014
2	Succinic Acid (Succinate)IBA 02/2013 - 10/2011
1	ProhibitinsIBA 01/2022
1	Glutamate DehydrogenaseIBA 01/2022
1	Guanosine Triphosphate (GTP)IBA 01/2022
1	KetonesIBA 01/2022
1	Nicotine FDA Link 01/2022
1	NitrosaminesIBA 01/2022
1	Superoxide DismutaseIBA 01/2022
1	Annexin A1IBA 01/2022
1	Ribosomal RNAIBA 10/2021
1	Bleomycin (Blenoxane)FDA LinkGeneric 04/2021
1	Neoplasm Antigens (Tumor Antigens)IBA 01/2021
1	A-factor (Streptomyces)IBA 01/2021
1	SolutionsIBA 02/2020
1	Ringer's LactateIBA 02/2020
1	DioxygenasesIBA 01/2020
1	Analgesics (Analgesic Drugs)IBA 12/2019
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 05/2019
1	trans-sodium crocetinate (crocetin)IBA 01/2019
1	Carbonic Anhydrase IXIBA 01/2019
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2019
1	m-AAA proteasesIBA 01/2019
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2019
1	Glutathione (Reduced Glutathione)IBA 12/2017
1	Adenosine Triphosphate (ATP)IBA 12/2017
1	Mitochondrial RNAIBA 10/2017
1	Hyaluronic Acid (Hyaluronan)IBA 09/2017
1	Protein Kinases (Protein Kinase)IBA 08/2017
1	Peptide Hydrolases (Proteases)FDA Link 01/2017
1	Apoptosis Regulatory ProteinsIBA 01/2017
1	Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA 01/2017
1	Hypoxia-Inducible Factor 1IBA 01/2017
1	Oxidoreductases (Dehydrogenase)IBA 01/2017
1	PlatinumIBA 01/2017
1	Carboplatin (JM8)FDA LinkGeneric 01/2017
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2017
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2017
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2017
1	NucleotidesIBA 08/2016
1	Interleukin-6 (Interleukin 6)IBA 02/2016
1	Phenobarbital (Luminal)FDA Link 02/2016
1	Carbonyl Cyanide m-Chlorophenyl Hydrazone (CCCP)IBA 11/2015

Therapy/Procedure

10	Therapeutics 10/2021 - 06/2015
4	Drug Therapy (Chemotherapy) 05/2018 - 11/2011
1	Cell Transplantation 12/2019
1	Transplantation 12/2019
1	Subcutaneous Injections 12/2019
1	Extracorporeal Shockwave Therapy 09/2017
1	Aftercare (After-Treatment) 01/2017
1	Conservative Treatment 07/2016
1	Exercise Therapy (Therapy, Exercise) 07/2016